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MYP_150441
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Basic Information
Diketopiperazine WP
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
2 amino acids
C16H19N3O3
Standard
Sequence
WP
Physicochemical Analysis
301.34 Da
5.53
-0.24
-0.44
-0.1200
-1.25
0.40
0.47
5.00
0.00
0.5000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
99.42
1.11
3.0
3.0
4.0
22.0
3.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076590 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
16 μg/mL
MIC
RECORD: Rec_0096000 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0098412 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
Human TAS2R1/TAS2R4/TAS2R14/TAS2R39/TAS2R46; HEK293 cells
PaperAmino acids and peptides activate at least five members of the human bitter taste receptor family. J. Agric. Food Chem., 61, 53-60 PMID23214402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23214402/
RECORD: Rec_0156914 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
64 μg/mL
MIC
RECORD: Rec_0167481 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
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