Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length434 amino acids

Chemical FormulaC2151H3422N532O627S12

DescriptionStandard

        MEVLIPIFSKGYVGRQIGLITLQEKLKTIKIPDLSGSEKVSPIGKVSYSLTGIQILNLGLPKSTVGLVPNTGVSFSIGDAYINLHGNWRVKYLRIIKDSGSFDLSVSGLGIGVTVCVKGDETGRPTVNSANCVASVDHVSIKFHGGASWLYNLFKDYIDKALRTALQNQICSLVDEAIDEMNPHLKTLNVLAQVDKYAEIEYSMVESPLISNSSIDLSLKGEFYNIGQHKEPPFSPTPFSLPAQDSSMLYIALSAFTLNSAGFVYDAAGVLNLYVTDDMIAKQYPGLMIKLLVKAEKEPDILFVPNNVTAQVSSLVTAYAIQPNATLSPLFVLNVNVSVSAQIYVSGIKVAGVLSLNEVDMGLVTSYVGPFQVKSLDSVFNMILKVVVIPKVNAYLKQGYPLPSIGKMNLLNTQLQILKDYVLIGTDVQFSHVY
    

Molecular Weight47152.15 Da

Isoelectric Point (pI)6.32

Net Charge (pH 7.0)-1.99

Net Charge (pH 7.4) -2.66

Charge Density (pH 7.0) -0.0046

GRAVY Index0.26

Hydrophobic Moment 0.75

Boman Index0.20

Instability Index24.47

Aliphatic Index 113.32

Aromaticity 0.0853

Extinction Coeff. Reduced 40800.00

Extinction Coeff. Oxidized 40925.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340080 VERIFIED: NO

Provenance & Taxonomy

OrganismBagarius yarrelli [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence