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MYP_150426
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Basic Information
V681
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C138H227N35O34
Standard
Sequence
KWKSFLKTFKSAVKTVLHTALKAISS
Physicochemical Analysis
2920.49 Da
10.70
5.84
5.58
0.2247
0.10
0.67
0.06
5.45
93.85
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1133.02
-8.86
42.0
41.0
100.0
207.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0255364 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Ser at 11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DC2
1.6 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0257383 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
The geometric mean of MIC values above six Gram-positive strains
6.3 μg/mL
MIC
PaperRational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 1;280(13):12316-29. doi: 10.1074/jbc.M413406200. PMID: 15677462. PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0259329 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Val at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa H188
8 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0262442 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Toxic Hemolytic Antitrypanosomal
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0270153 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa H187
2 μg/mL
MIC
PaperRational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 1;280(13):12316-29. doi: 10.1074/jbc.M413406200. PMID: 15677462. PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
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