Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length493 amino acids

Chemical FormulaC2419H3939N635O680S20

DescriptionStandard

        MFLCCWLALTALIPLTLSTNPGVKVKLTAKGLEYGRQLGMVSIQKKLKTIKVPDMSGKQRVSPIGKVKYSLTNIQIVDVGLPTSALDLVPGTGVRLSIAKAFINLHGNWRVKYLRVIKDSGSFDLKVSGLTVTTSIAIKSDETGRPVVSTVNCVAKVGSVSVKFHGGASWLYNLFKKFVEKALRNALDKKICTLVGDAVTDLNPQLKTLNVVAKVDKYAEIEYSMVSAPAVTKASIEFGMKGEFYNIGKHQEPPFTAAAFSLPPETDRMLYIGLSAFTANSAAYVYNTAGALSLDITDDMIPRGSPIRLNTRTFYVFLPQLAKRFPGLMMKLLVRTAKAPVVTFEPNKATVEASSTVTAYAIQPNATLSPLFVLNMETSASARVFVSGMRLAGAVNLNKMDLTLGKSYVGDFQVRTLNSIFQTVLKLVVIPILNVQLAKGYPLPALGKMNLVNTQLQVLKEHVSIMVVSEAPCSRSRSLGAVSQCPTVPLREL
    

Molecular Weight53439.30 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)25.80

Net Charge (pH 7.4) 25.18

Charge Density (pH 7.0) 0.0523

GRAVY Index0.22

Hydrophobic Moment 0.80

Boman Index0.13

Instability Index29.48

Aliphatic Index 104.56

Aromaticity 0.0730

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37735.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0350430 VERIFIED: NO

Provenance & Taxonomy

OrganismLiparis tanakae [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence