‹ ›
MYP_150331
← PREVIOUS NEXT → BACK
Basic Information
VIRIP[A13,C6,C11,F12]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C109H158N22O25S2
Standard
Sequence
LEAIPCSIPPCFAFNKPFVF
Physicochemical Analysis
2240.68 Da
5.99
-0.26
-0.49
-0.0129
0.94
0.31
0.44
26.41
83.00
0.2000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
707.70
-1.84
23.0
27.0
62.0
158.0
8.0
20.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0176607 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 LAI L536F
0.15 μg/mL
IC50
PMID30696772 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30696772/
RECORD: Rec_0193001 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VIRIP-derived peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-11
Disulfide bond between Cys6 and Cys11
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1
0.27±0.04 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. | Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F. | Cell. 2007 Apr 20;129(2):263-75. | DOI:10.1016/j.cell.2007.02.042 | PMID:17448989 PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0199031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-11
Bio-Activity Profile
Antimicrobial Antiviral
P4-CCR5 cells up tp 1000 μM
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0344649 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 LAI I515T
0.39 μg/mL
IC50
PMID30696772 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30696772/
RECORD: Rec_0347392 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 LAI I515F
14.05 μg/mL
IC50
PMID30696772 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30696772/
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3