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MYP_150331
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Basic Information
VIRIP[A13,C6,C11,F12]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
20 amino acids
C109H158N22O25S2
Standard
Sequence
LEAIPCSIPPCFAFNKPFVF
Physicochemical Analysis
2240.68 Da
5.99
-0.26
-0.49
-0.0129
0.94
0.31
0.44
26.41
83.00
0.2000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
707.70
-1.84
23.0
27.0
62.0
158.0
8.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021725 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VIRIP-derived peptide
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-11
Disulfide bond between Cys6 and Cys11
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1; P4-CCR5 cells
0.27±0.04 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0075901 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 LAI
1.31 μg/mL
IC50
PMID30696772 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30696772/
RECORD: Rec_0086779 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 45.0%, C 55.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0093842 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VIRIP-derived peptide
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-11
Disulfide bond between Cys6 and Cys11
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
HIV-1; P4-CCR5 cells
HIV-1 entry inhibition assay
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0104277 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
VIRIP
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
P4-CCR5
Qualitative inhibition
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
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