Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length188 amino acids

Chemical FormulaC943H1496N266O250S10

DescriptionStandard

        PMALATEHEPMLLLAITEFVANSAAFTYFTAGALQRNISSDMLPRRFPLKLKTKSMGLFSPQLQERYPDHPMELRLSARQQPRLSCRPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPIFTSNRLGGRPCLRRGPLCLPRAGLRGLSFPQVKRLENLLKFALWLFGVPWANSECCPHSVP
    

Molecular Weight20880.25 Da

Isoelectric Point (pI)10.05

Net Charge (pH 7.0)10.28

Net Charge (pH 7.4) 9.92

Charge Density (pH 7.0) 0.0547

GRAVY Index-0.01

Hydrophobic Moment 0.66

Boman Index0.05

Instability Index54.58

Aliphatic Index 90.90

Aromaticity 0.0851

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8141.78

LogP -94.59

H-bond Donors 285.0

H-bond Acceptors 274.0

Rotatable Bonds 666.0

Heavy Atoms 1469.0

Ring Count 41.0

Amide Bonds 201.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296038 VERIFIED: NO

Provenance & Taxonomy

OrganismUria aalge (Common mure) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria