Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length175 amino acids

Chemical FormulaC836H1346N222O247S8

DescriptionStandard

        MQVVICFLMILTHTYADYPALKTVLSEKGLRDVSQMMAVWIQSKLKSTTIPEVHGGVDIGIGTVHYVISNHDGGSLDLAVYNIKIQTLLELGDDTGRVSITTVSCSDGIGGVNIQFHGGARSGTIDVHVLAAAKFSVVKPDGMLVPLFRLDVDGSFSGSALIDKKHLTGAFNMKK
    

Molecular Weight18715.49 Da

Isoelectric Point (pI)6.64

Net Charge (pH 7.0)-0.90

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0052

GRAVY Index0.27

Hydrophobic Moment 0.70

Boman Index0.19

Instability Index22.51

Aliphatic Index 106.29

Aromaticity 0.0629

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11585.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7433.44

LogP -79.00

H-bond Donors 260.0

H-bond Acceptors 261.0

Rotatable Bonds 626.0

Heavy Atoms 1313.0

Ring Count 23.0

Amide Bonds 183.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0244074 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence