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MYP_150192
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Basic Information
CPF-8
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C111H184N28O18
Standard
Sequence
WFKKLLKKALRLWKKVL
Physicochemical Analysis
2198.83 Da
11.43
6.75
6.54
0.3973
-0.11
0.88
-0.10
10.85
137.65
0.1765
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
778.52
1.79
29.0
25.0
78.0
157.0
5.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0187267 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa 2760
16 μg/mL
MIC
PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0191681 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii ATCC 19606
8 μg/mL
MIC
PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0204001 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii 2982
8 μg/mL
MIC
PaperNovel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria. Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988. PMID: 28371431. PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0207019 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 794
8 μg/mL
MIC
PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0219723 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli 804; Escherichia coli 850; Staphylococcuss aureus ATCC 25923; Escherichia coli ATCC 25922; Pseudomonas aeruginosa 9132; Pseudomonas aeruginosa ATCC 27853; Acinetobacter baumannii 4956; Escherichia coli 780; Acinetobacter baumannii 2982; Pseudomonas aeruginosa 2760; Staphylococcuss aureus 794; human red blood cells; Staphylococcuss aureus 725
MIC
PaperNovel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria. Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988. PMID: 28371431. PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
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