Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length452 amino acids

Chemical FormulaC2288H3554N568O662S18

DescriptionStandard

        MRTKAVQVLWGCFLLWDLYVSSAQTVYPGIKARVTQRALDYGVLAGMEMTEHMVKEKNIPDLEGSESLEFLKVDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIKSPLFEDAGGADLFLSGVYFTGIVVLARNDFGHPILKLQRCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFLPVPFALPERHDSMLYVGISEFFFKSASFAYFTSGAFNVTLSLKEISSHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASMVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSLLHFGILPLANGVPFDFHRPEV
    

Molecular Weight50187.27 Da

Isoelectric Point (pI)4.96

Net Charge (pH 7.0)-16.68

Net Charge (pH 7.4) -17.52

Charge Density (pH 7.0) -0.0369

GRAVY Index0.23

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index37.55

Aliphatic Index 104.36

Aromaticity 0.1040

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0253787 VERIFIED: NO

Provenance & Taxonomy

OrganismZalophus californianus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria