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MYP_150169
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Basic Information
E3 ubiquitin-protein ligase TRIM22
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Regulatory peptide ▸ Biological modulation
Standard
498 amino acids
C2523H3974N692O751S29
Standard
Sequence
MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
Physicochemical Analysis
56946.61 Da
7.97
3.08
2.01
0.0062
-0.37
0.75
-0.05
41.78
81.71
0.0924
67840.00
69090.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0161002 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
TRIM
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-EMCV
Encephalomyocarditis virus(EMCV)
PaperTRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. PMID19218198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19218198/
RECORD: Rec_0233873 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
TRIM
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor Interferon pathway modulator Anti-HIV
Human immunodeficiency virus (HIV)
PaperThe interferon response inhibits HIV particle production by induction of TRIM22. PMID18389079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18389079/
RECORD: Rec_0280480 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
TRIM
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Transcription regulator Anti-HBV
Hepatitis B virus(HBV)
PaperTripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. PMID19585648 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19585648/