‹ ›
MYP_150167
← PREVIOUS NEXT → BACK
Basic Information
A4K14-citropin1.1-Sp5
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C79H139N19O18
Standard
Sequence
GLFAVIKKVASVIKGL
Physicochemical Analysis
1643.07 Da
10.30
2.76
2.55
0.1723
1.39
0.64
0.43
-11.85
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
598.11
-2.25
21.0
21.0
57.0
116.0
1.0
15.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0334026 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Leuconostoc lactis
3 μg/mL
MIC
PMID12631273;30240951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0337608 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 9 and 13) in sequence indicate (S)-2-(4-pentenyl)alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
C4-2B
8.90 μM
IC50
α-chymotrypsin-mediated degradation: >10 h
PaperNan Wang, Gang Xie, Chao Liu, Wei Cong, Shipeng He, Yinghua Li, Li Fan, Hong-Gang Hu. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. doi: 10.3389/fchem.2020.616147. eCollection 2020. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0348198 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicate (S)-2-(4-pentenyl)alanine. Ⓧ (6) and Ⓧ (10) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
U87
11.93 μM
IC50
PaperNan Wang, Gang Xie, Chao Liu, Wei Cong, Shipeng He, Yinghua Li, Li Fan, Hong-Gang Hu. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. doi: 10.3389/fchem.2020.616147. eCollection 2020. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0355803 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 9 and 13) in sequence indicate (S)-2-(4-pentenyl)alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
U87
7.277 μM
IC50
α-chymotrypsin-mediated degradation: >10 h
PaperNan Wang, Gang Xie, Chao Liu, Wei Cong, Shipeng He, Yinghua Li, Li Fan, Hong-Gang Hu. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. doi: 10.3389/fchem.2020.616147. eCollection 2020. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0359474 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
FIRST PREV 1 ... 7 8 9 10 11 12 NEXT LAST
Showing 5 records on this page · Page 9 of 12