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MYP_150147
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Basic Information
Caerin-1.6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Standard
24 amino acids
C118H194N30O28
Standard
Sequence
GLFSVLGAVAKHVLPHVVPVIAEK
Physicochemical Analysis
2480.99 Da
8.61
0.94
0.63
0.0390
1.12
0.43
0.44
30.12
150.00
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
881.97
-3.71
29.0
31.0
77.0
176.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046339 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Anticancer nNOS inhibitor
PaperP.A. Wabnitz et al. / European Journal of Biochemistry 267 (2000) 269-275. Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10 Evidence URLhttps://www.uniprot.org/uniprotkb/P62546/entry
RECORD: Rec_0052487 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
19.27 μM
MIC
PaperP.A. Wabnitz et al. / European Journal of Biochemistry 267 (2000) 269-275. Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10 Evidence URLhttps://www.uniprot.org/uniprotkb/P62546/entry
RECORD: Rec_0113554 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Caerin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9516047/
RECORD: Rec_0131669 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
2.31 μM
MIC
PaperP.A. Wabnitz et al. / European Journal of Biochemistry 267 (2000) 269-275. Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10 Evidence URLhttps://www.uniprot.org/uniprotkb/P62546/entry
RECORD: Rec_0164459 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Blue-thighed frog,Litoria chloris, Australia
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
PMID9230483;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9230483/
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