Peptide Database

Peptide NameEosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Hydrolase ▸ Nuclease

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length160 amino acids

Chemical FormulaC807H1280N252O218S12

DescriptionStandard

        MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
    

Molecular Weight18385.13 Da

Isoelectric Point (pI)10.12

Net Charge (pH 7.0)12.94

Net Charge (pH 7.4) 12.27

Charge Density (pH 7.0) 0.0809

GRAVY Index-0.28

Hydrophobic Moment 0.73

Boman Index-0.07

Instability Index59.06

Aliphatic Index 84.06

Aromaticity 0.0813

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 17460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7579.76

LogP -79.83

H-bond Donors 271.0

H-bond Acceptors 249.0

Rotatable Bonds 584.0

Heavy Atoms 1289.0

Ring Count 34.0

Amide Bonds 181.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413877 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyPancreatic ribonuclease

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Endonuclease Hydrolase Nuclease Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)