Peptide Database

Peptide NameAscaphin-8-2

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC98H165N23O25

DescriptionStandard

        GFKDLLKSAAKSLVKTVLF
    

Molecular Weight2065.50 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.1451

GRAVY Index0.58

Hydrophobic Moment 0.67

Boman Index0.17

Instability Index-4.42

Aliphatic Index 123.16

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 789.19

LogP -4.87

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 72.0

Heavy Atoms 146.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0127061 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetHEK293T

Activity19.72 μM

MethodIC50

RECORD: Rec_0181555 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetC4-2B

Activity7.88 μM

MethodIC50

RECORD: Rec_0370429 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetA549

Activity2.57 μM

MethodIC50

RECORD: Rec_0386162 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Hemolytic

Targetrabbit RBCs

Activity40.17 μM

MethodHC50