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MYP_150084
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Basic Information
Casein beta [060-063]
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
4 amino acids
C28H34N4O6
Standard
Sequence
YPFP
Physicochemical Analysis
522.59 Da
5.52
-0.24
-0.45
-0.0602
-0.42
0.23
0.42
134.65
0.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
153.27
1.06
4.0
6.0
9.0
38.0
4.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0350119 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0356841 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Opioid peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
RECORD: Rec_0368215 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Opioid receptor ligand
PaperBiologically active peptides in milk proteins | Meisel, H. et al. | DOI: 10.1007/BF02019390 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0390938 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic Anti-breast cancer Cell-proliferative
decreased breastcancer cell proliferation
Cell proliferation assay
PaperAntiproliferative and receptor binding properties of α- and β-casomorphins in the T47D human breast cancer cell line | Hatzoglou, A. et al. | DOI: 10.1016/0014-2999(96)00339-1 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0402512 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Endomorphin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive
Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Endomorphin-2 (Bos taurus): PMID 20434497 PMID20434497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20434497/
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