Peptide Database

Peptide NameSLAY-screened peptide P3880

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC91H150N34O28S3

DescriptionStandard

        HTRCCGDPSSPKHLARPMRD
    

Molecular Weight2264.57 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.0959

GRAVY Index-1.29

Hydrophobic Moment 0.70

Boman Index-0.42

Instability Index49.05

Aliphatic Index 24.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 994.22

LogP -13.40

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 70.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0223369 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/