Peptide Database

Peptide NameChassatide C8 (Cyclotide chaC8)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length75 amino acids

Chemical FormulaC363H579N93O104S10

DescriptionStandard

        MAKFANYLMLFLLVASLVMLEAQSSDTIKAPDWGKRLLMNHDSDLGAIPCGESCVWIPCISTVIGCSCSNKVCYR
    

Molecular Weight8230.69 Da

Isoelectric Point (pI)6.50

Net Charge (pH 7.0)-0.47

Net Charge (pH 7.4) -0.84

Charge Density (pH 7.0) -0.0062

GRAVY Index0.47

Hydrophobic Moment 0.58

Boman Index0.21

Instability Index27.88

Aliphatic Index 100.13

Aromaticity 0.0800

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3117.41

LogP -26.99

H-bond Donors 114.0

H-bond Acceptors 115.0

Rotatable Bonds 268.0

Heavy Atoms 570.0

Ring Count 12.0

Amide Bonds 78.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071912 VERIFIED: NO

Provenance & Taxonomy

OrganismChassalia chartacea [Plant]

FamilyCyclotide

Structure & Mods

Configbackbone-cyclized cyclotide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0248022 VERIFIED: YES