‹ ›
MYP_150026
← PREVIOUS NEXT → BACK
Basic Information
Adamtsostatin-18
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
19 amino acids
C89H141N29O29S2
Standard
Sequence
SKWSECSRTCGGGVKFQER
Physicochemical Analysis
2145.38 Da
8.88
1.44
1.20
0.0760
-1.08
0.47
-0.31
74.48
15.26
0.1053
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
977.36
-13.36
38.0
33.0
73.0
149.0
3.0
19.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0021873 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
HUVEC
Boyden chamber migration assay
PaperAnti-angiogenic peptides identified in thrombospondin type I domains PMID17531201 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17531201/
RECORD: Rec_0030612 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0068711 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
HUVEC
WST-1 proliferation assay
PaperAnti-angiogenic peptides identified in thrombospondin type I domains PMID17531201 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17531201/
RECORD: Rec_0071010 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0114038 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
Endothelial screening context
PaperSupporting Information for Karagiannis and Popel, PNAS (10.1073/pnas.0803241105) PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2