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MYP_149911
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Basic Information
B1-GG-C10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C98H165N29O19
Standard
Sequence
GGVKRFKKFFRKLKKSV
Physicochemical Analysis
2053.54 Da
12.00
7.75
7.54
0.4561
-0.79
0.95
-0.38
15.32
57.06
0.1765
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
829.07
-5.20
31.0
27.0
76.0
146.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0117779 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)14CO, Palmitic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7/Taxol
11.5±0.8 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0119775 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)8CO, Decanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: MCF-7
2.7±0.3 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0121087 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)8CO, Decanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: <20% Hemolysis =160 μM
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0128625 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)16CO, Octadecanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
9.6±0.4 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0132135 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)12CO, Myristic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: MCF-7
3.5±0.1 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
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