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MYP_149823
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Basic Information
U3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KXWKLXK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0336036 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
18.8 μg/mL
MIC
PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0375788 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
12.5 μg/mL
MIC
PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0383349 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic noncanonical linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Positions 2 and 6: (S)-α-methyl-α-pentenylglycine; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
100 μM
MIC
PaperMono-substitution effects on antimicrobial activity of stapled heptapeptides. PMID:28547390 PMID28547390 Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP21608 PatentKR101930125B1
RECORD: Rec_0383541 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic noncanonical linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Positions 2 and 6: (S)-α-methyl-α-pentenylglycine; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 10031
50 μM
MIC
PaperMono-substitution effects on antimicrobial activity of stapled heptapeptides. PMID:28547390 PMID28547390 Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP21608 PatentKR101930125B1
RECORD: Rec_0412305 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic noncanonical linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Positions 2 and 6: (S)-α-methyl-α-pentenylglycine; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis ATCC 12228
100 μM
MIC
PaperMono-substitution effects on antimicrobial activity of stapled heptapeptides. PMID:28547390 PMID28547390 Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP21608 PatentKR101930125B1
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