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MYP_149823
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Basic Information
U3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KXWKLXK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189991 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic noncanonical linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Positions 2 and 6: (S)-α-methyl-α-pentenylglycine; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028
>100 μM
MIC
PaperMono-substitution effects on antimicrobial activity of stapled heptapeptides. PMID:28547390 PMID28547390 Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP21608 PatentKR101930125B1
RECORD: Rec_0190548 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 6538P
25 μg/mL
MIC
PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0197596 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella dysenteriae ATCC 9752
50 μg/mL
MIC
PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0198228 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Hemolytic
Human erythrocytes
25-50 μM
Hemolysis
PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0213878 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic noncanonical linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Positions 2 and 6: (S)-α-methyl-α-pentenylglycine; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
Bacterial panel (eight strains; see assay context)
Broth microdilution MIC panel
PaperMono-substitution effects on antimicrobial activity of stapled heptapeptides. PMID:28547390 PMID28547390 Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP21608 PatentKR101930125B1
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