Peptide Database

Peptide NameSLAY-screened peptide P4900

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC70H101N21O21

DescriptionStandard

        PNSGSHSVPHAWPTV
    

Molecular Weight1572.68 Da

Isoelectric Point (pI)7.33

Net Charge (pH 7.0)0.13

Net Charge (pH 7.4) -0.03

Charge Density (pH 7.0) 0.0089

GRAVY Index-0.59

Hydrophobic Moment 0.33

Boman Index0.15

Instability Index22.17

Aliphatic Index 45.33

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 636.31

LogP -8.53

H-bond Donors 22.0

H-bond Acceptors 23.0

Rotatable Bonds 41.0

Heavy Atoms 112.0

Ring Count 7.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0244807 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/