Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length511 amino acids

Chemical FormulaC2560H3987N637O734S22

DescriptionStandard

        MLPSLLVLLTLMPHAFAINPGIKASLSDKGLKYGSHVGASWLLEKTGQMVIPDVAGEIDIGIGTVHYWLTSMKISQINLPEPTVTFMEKVGIKVSMENLNVAVHGNWNTKFSFIKDGGTFDLAVINVGLSTVIQLGSDGKGHLSVANVQCSSSIGGIDASFHGGGSFIFQPFVHFFKSKILNQIQEKICPGIEKYVNDLESQLEKMQVSFQVNRNLSIELPLVLPPIIQSSDVEVDLKGVFYGARNHTDPPFAAGPFQLVQQSDLMLTVGLSEFTINSASFAYYSAGLLQILITDDMIPKASPFRLNTTSFGTLIPQLPKMYPNMLMLLRAYAAQTPTVSFHPDTTTLNVFVSTKAYGIKPNATYIPFFRLDMNATLSSKFFISDEKLSGSTALDNLTLTVGATEIGPFQVEKDICVCNKDLDFKTLINASYGYISRTLPHSTASWATYDLLGLCHFLTIHKQSFIFLCTVSLNFPTSSFYSRLKMLINSSSNILYPHCQSQYCITLHLAV
    

Molecular Weight56137.30 Da

Isoelectric Point (pI)6.53

Net Charge (pH 7.0)-2.33

Net Charge (pH 7.4) -3.48

Charge Density (pH 7.0) -0.0046

GRAVY Index0.21

Hydrophobic Moment 0.63

Boman Index0.20

Instability Index33.86

Aliphatic Index 99.00

Aromaticity 0.1018

Extinction Coeff. Reduced 45840.00

Extinction Coeff. Oxidized 46340.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0142239 VERIFIED: NO

Provenance & Taxonomy

OrganismParamormyrops kingsleyae [Bacterium]

FamilyBPI

Tax ID1676925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence