Peptide Database

Peptide NameTemporin L[Pro3,DLeu9,Trp10](TL10)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC92H127N19O15

DescriptionStandard

        FVPWFSKFLWRIL
    

Molecular Weight1739.11 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1353

GRAVY Index0.93

Hydrophobic Moment 0.61

Boman Index0.44

Instability Index54.86

Aliphatic Index 112.31

Aromaticity 0.3846

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 543.46

LogP 3.08

H-bond Donors 20.0

H-bond Acceptors 17.0

Rotatable Bonds 50.0

Heavy Atoms 126.0

Ring Count 8.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417310 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HCoV-OC43 Replication inhibition

TargetHCoV-OC43 | Vero cells

Activity24.17 μM

MethodIC90

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/

RECORD: Rec_0418785 VERIFIED: YES