Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC165H248N42O51S

DescriptionStandard

        GELDELVYLLDGPGYDPIHCDVVTRGGSRLFNF
    

Molecular Weight3668.05 Da

Isoelectric Point (pI)4.23

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.43

Charge Density (pH 7.0) -0.1259

GRAVY Index-0.05

Hydrophobic Moment 0.73

Boman Index0.13

Instability Index19.18

Aliphatic Index 97.27

Aromaticity 0.1212

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1477.23

LogP -11.99

H-bond Donors 51.0

H-bond Acceptors 49.0

Rotatable Bonds 115.0

Heavy Atoms 259.0

Ring Count 7.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0274207 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 0.0%, T 24.2%, C 75.8% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0352792 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Protease inhibitor Replication inhibitor

TargetHepatitis C virus (Replication); Escherichia coli

Activity0.00114 μM

MethodFRET assay

PaperHigh affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. | Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J. | J Biol Chem. 2012 | PMID:22965230 PMID22965230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965230/