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MYP_149548
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Basic Information
Fp16
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C181H302N50O62
Standard
Sequence
GINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
Physicochemical Analysis
4170.63 Da
4.62
-3.22
-3.44
-0.0871
-0.42
0.70
-0.05
37.37
123.78
0.0270
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1874.30
-18.70
61.0
59.0
149.0
293.0
1.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0151047 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | E6 cells
19 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInteraction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. | Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S. | Lancet. 2004 Mar 20;363(9413):938-47. | DOI:10.1016/j.antiviral.2008.10.001. | PMID:15043961 PMID15043961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15043961/
RECORD: Rec_0165238 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
SARS coronavirus (Virus entry); HeLa
0.62 μM
beta-galactosidase activity
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0176952 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor Cytoprotective
SARS coronavirus (Fusion); Vero E6
19 μM
Cytopathic effect
PaperInteraction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. | Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S. | Lancet. 2004 | PMID:15043961 PMID15043961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15043961/
RECORD: Rec_0200119 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of the cytopathic effect in Vero E6 cells(IC50~19 μM/L)
PMID18983873;15043961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0203600 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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