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MYP_149548
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Basic Information
Fp16
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C181H302N50O62
Standard
Sequence
GINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
Physicochemical Analysis
4170.63 Da
4.62
-3.22
-3.44
-0.0871
-0.42
0.70
-0.05
37.37
123.78
0.0270
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1874.30
-18.70
61.0
59.0
149.0
293.0
1.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017297 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID34591335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34591335/
RECORD: Rec_0057222 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
19 μM
IC50
PaperInteraction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors PMID15043961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15043961/
RECORD: Rec_0069092 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | of cell; Hela cells
0.62±0.2 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 Jan;81(1):82-7. | DOI:10.1016/j.antiviral.2008.10.001 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0127873 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
3.04 μM
IC50
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0139376 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID18983873;15043961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
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