Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length469 amino acids

Chemical FormulaC2381H3751N605O682S17

DescriptionStandard

        MVKICCSLLLLSLLSVQLKANPGLKVRITQKALEYAKKVGVEILKKNMEKEQFPDLIGYERFGLGNVHYNISRIRVTAVEFPNVSISLIPRSGVKLVIRNASLTIDMNWNIRTWMFKDGGRSTVHISKVFVTATFSTPLDSIGHTSVSLSSCHTTSGDTDIKVNGKSGFLHDFFIKYLKKPIHRSLATNSCPNIRSGIQMIAKDFQSLNVPVRIDDLAEIDYSLNSLEVFRPYIDMDLKGIVYPAGNYTGPPYVATPFAIPDQNDSMLYLAFSEYFFQTSLFSYYTAGAFNITIAKETCRYLNISTEMFGSIIPEIAKYPIIPYPVMMKLTATEIPLVSLQQDSFTLEIRESMEVFAVLPDSTTQSLFTVNVAANTSIALNVFDQKLTGSLCLNRLQFSLAHSNVGSFEISFLENILSYILQTEVIPSANAKLSKGFPLPNLANIILTRPHITIAQGYVLISTDAHYKH
    

Molecular Weight52309.00 Da

Isoelectric Point (pI)8.54

Net Charge (pH 7.0)4.34

Net Charge (pH 7.4) 3.42

Charge Density (pH 7.0) 0.0093

GRAVY Index0.13

Hydrophobic Moment 0.77

Boman Index0.14

Instability Index38.63

Aliphatic Index 102.47

Aromaticity 0.1002

Extinction Coeff. Reduced 39310.00

Extinction Coeff. Oxidized 39685.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0140980 VERIFIED: YES

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyBPI/LBP

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria