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MYP_149384
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Basic Information
ACE2 (37-45)(SAP2)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
9 amino acids
C50H72N10O18
Standard
Sequence
EDLFYQSSL
Physicochemical Analysis
1101.16 Da
4.05
-2.16
-2.33
-0.2403
-0.33
0.16
0.08
136.73
86.67
0.2222
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
474.50
-3.85
16.0
16.0
35.0
78.0
2.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076835 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0222896 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
3.72 μM
IC50
PaperRationally designed ACE2-derived peptides inhibit SARS-CoV-2 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0293055 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 PsV
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0350636 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells
3720±370 μM
IC50
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0411272 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | 293T/ACE2 cells
3720±370 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/