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MYP_149324
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Basic Information
Feleucin-BO1 (toads, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
9 amino acids
C46H77N9O11
Standard
Sequence
FLGLLGSLL
Physicochemical Analysis
932.16 Da
5.53
-0.24
-0.44
-0.0267
2.24
0.37
0.81
8.89
216.67
0.1111
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
316.35
0.01
11.0
11.0
30.0
66.0
1.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165737 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Horse RBCs
250 μM
Hemolysis
PMID25056849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25056849/
RECORD: Rec_0194031 VERIFIED: YES
Provenance & Taxonomy
Asian bombinid [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID25056849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25056849/
RECORD: Rec_0204904 VERIFIED: YES
Provenance & Taxonomy
Asian bombinid [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
3 μM
MIC
PMID25056849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25056849/
RECORD: Rec_0262897 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Oriental fire-bellied toad [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C-terminal amidation
Bio-Activity Profile
Antimicrobial
the antibacterial activity of the peptide was enhanced
7-14 μM
MIC
PaperFeleucin-BO1: a novel antimicrobial nonapeptide amide from the skin secretion of the toad, Bombina orientalis, and design of a potent broad-spectrum synthetic analogue, feleucin-K3.
RECORD: Rec_0265688 VERIFIED: YES
Provenance & Taxonomy
Asian bombinid [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
12 μM
MIC
PMID25056849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25056849/
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