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MYP_149304
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Basic Information
Hl Defensin-1, HlDFS1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C177H294N72O43S6
Standard
Sequence
GFGCPFNARRCHRHCRSIRRRAGYCAGRLRLTCTCVR
Physicochemical Analysis
4311.07 Da
11.41
9.87
9.48
0.2669
-0.52
0.84
-0.39
102.16
47.57
0.0811
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1902.50
-24.06
80.0
61.0
140.0
298.0
6.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0123865 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli CMCC 44103
5 μM
MIC90
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0132924 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Mycobacterium bovis
0.5 μM
MIC90
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0146046 VERIFIED: YES
Provenance & Taxonomy
Haemaphysalis longicornis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
M. bovis
0.5 μM
MIC
PaperFunctional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis
RECORD: Rec_0150541 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
>50 μM
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0169558 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
(Not active up to 20 μM)
PaperPubMed PMID: 28969703 PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
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