‹ ›
MYP_149304
← PREVIOUS NEXT → BACK
Basic Information
Hl Defensin-1, HlDFS1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C177H294N72O43S6
Standard
Sequence
GFGCPFNARRCHRHCRSIRRRAGYCAGRLRLTCTCVR
Physicochemical Analysis
4311.07 Da
11.41
9.87
9.48
0.2669
-0.52
0.84
-0.39
102.16
47.57
0.0811
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1902.50
-24.06
80.0
61.0
140.0
298.0
6.0
37.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0102385 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human acute monocytic leukemia THP-1
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0113543 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus CMCC 26003
50 μM
MIC90
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0115992 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli
>50 μM
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0122098 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0122574 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
THP-1 (Not active up to 20 μM)
PaperPubMed PMID: 28969703 PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
FIRST PREV 1 2 3 4 5 ... 9 NEXT LAST
Showing 5 records on this page · Page 3 of 9