Peptide Database

Peptide NamesHR2-3

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length56 amino acids

Chemical FormulaC277H446N74O94

DescriptionStandard

        LDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
    

Molecular Weight6316.94 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-5.13

Net Charge (pH 7.4) -5.41

Charge Density (pH 7.0) -0.0917

GRAVY Index-0.55

Hydrophobic Moment 0.70

Boman Index-0.06

Instability Index26.35

Aliphatic Index 107.86

Aromaticity 0.0536

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2772.34

LogP -28.00

H-bond Donors 91.0

H-bond Acceptors 90.0

Rotatable Bonds 220.0

Heavy Atoms 445.0

Ring Count 5.0

Amide Bonds 63.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0072974 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2-derived fusion inhibitor

Tax ID694009

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Fusion inhibition

TargetSARS-CoV; Vero cells

Activity>50 μM

MethodIndirect immunofluorescence virus-infection inhibition assay (EC50)

RECORD: Rec_0288042 VERIFIED: YES