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MYP_149261
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Basic Information
Ranatuerin-2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
31 amino acids
C143H247N37O40S2
Standard
Sequence
GLFLDTLKGAAKDVAGKLEGLKCKITGCKLP
Physicochemical Analysis
3188.84 Da
9.19
2.74
2.50
0.0884
0.19
0.54
0.11
-13.61
107.10
0.0323
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1236.01
-9.90
44.0
45.0
112.0
222.0
2.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0253911 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolysis tested Antimicrobial
Human erythrocytes
Hemolysis assay
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/; https://www.uniprot.org/uniprotkb/P82742/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0335437 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0338206 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
60 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0381274 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
23-28
Disulfide bridge: C23,C28;
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
60 μM
MIC
PaperRanatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana. PMID9784389
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