Peptide Database

Peptide NameAcD4

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC216H346N72O51

DescriptionStandard

        GYGYGYGYGYGYGYGYKKRKKRKKRKKRKQQKQQKRRK
    

Molecular Weight4767.51 Da

Isoelectric Point (pI)10.71

Net Charge (pH 7.0)17.74

Net Charge (pH 7.4) 17.51

Charge Density (pH 7.0) 0.4668

GRAVY Index-2.67

Hydrophobic Moment 0.32

Boman Index-0.81

Instability Index56.77

Aliphatic Index 0.00

Aromaticity 0.2105

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 11920.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2157.86

LogP -20.84

H-bond Donors 81.0

H-bond Acceptors 69.0

Rotatable Bonds 175.0

Heavy Atoms 339.0

Ring Count 8.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0137319 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAcD4

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

TargetHeLa, CHO and Jurkat cells

MethodFlow-cytometry/confocal-microscopy cellular uptake assay