Peptide Database

Peptide NamePuroindoline-B (35-46)[P2,6R], PuroB3

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC81H115N23O15

DescriptionStandard

        FRVTWRTKWWKG
    

Molecular Weight1650.92 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.3132

GRAVY Index-1.19

Hydrophobic Moment 0.12

Boman Index-0.25

Instability Index-17.51

Aliphatic Index 24.17

Aromaticity 0.3333

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 647.09

LogP -2.02

H-bond Donors 26.0

H-bond Acceptors 19.0

Rotatable Bonds 50.0

Heavy Atoms 119.0

Ring Count 7.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0365114 VERIFIED: YES

Provenance & Taxonomy

Organismporcine cathelicidin peptide [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetJurkat

Activity65 μM

MethodIC50

RECORD: Rec_0423649 VERIFIED: YES