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MYP_149232
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Basic Information
Puroindoline-B (35-46)[P2,6R], PuroB3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C81H115N23O15
Standard
Sequence
FRVTWRTKWWKG
Physicochemical Analysis
1650.92 Da
12.00
3.76
3.55
0.3132
-1.19
0.12
-0.25
-17.51
24.17
0.3333
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
647.09
-2.02
26.0
19.0
50.0
119.0
7.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (50% Hemolysis at >600 microM, Human PBMC (IC50 at >=65 microM
600 μM
Hemolysis
PMID23562406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23562406/
RECORD: Rec_0092338 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
3.0 μM
MIC
PMID23562406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23562406/
RECORD: Rec_0269741 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Jurkat T-cell leukemia
PMID23562406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23562406/
RECORD: Rec_0280019 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
6 μM
MIC
PMID23562406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23562406/
RECORD: Rec_0280336 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
RBC
65 μM
IC50
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
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