Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length329 amino acids

Chemical FormulaC1658H2598N462O467S8

DescriptionStandard

        MMARLYCVVVTLLLLAEVSGFEEGATNPGVVARITRKGLAYARQLGVAILKKELSTIKLPDFSGSFKVSWIKTVSYDFYRLTIHRFELRNSDLRLRPRQGVRASLSNNYMFVSGNWKVKKAFVTLDGTFDANVDGISISVSLNLGKDQSGRPTASVAHCRNSIGHISVDISGQLSWILNLLHKRIENNFKNILEQKIREMVRKSTTSHLEPYLRTPPVSSRIDQVAGIDYSLVGAPKVTSQVLDTPFKGEFFGQNWHSPALFDAPPIRLPEKHDHMVYFAVSEYVFNTASQVYHQAGLMNFTIQNHHIPPGLSNPPAHQLIPGHYSSAG
    

Molecular Weight36731.70 Da

Isoelectric Point (pI)9.63

Net Charge (pH 7.0)11.63

Net Charge (pH 7.4) 10.66

Charge Density (pH 7.0) 0.0354

GRAVY Index-0.15

Hydrophobic Moment 0.75

Boman Index0.05

Instability Index33.69

Aliphatic Index 91.82

Aromaticity 0.0942

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0123046 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence