Peptide Database

Peptide NameBeta-defensin 18

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length85 amino acids

Chemical FormulaC447H676N110O124S11

DescriptionStandard

        MQSAMKLFFIFLIFVFSVSCGPSAPQMKTRDVLERTHKCFLVGGECKSECSSWEYEYVFCYTGPCCVMREYKRVEKFSNTPKYTT
    

Molecular Weight9927.53 Da

Isoelectric Point (pI)8.50

Net Charge (pH 7.0)2.53

Net Charge (pH 7.4) 2.13

Charge Density (pH 7.0) 0.0297

GRAVY Index-0.10

Hydrophobic Moment 0.75

Boman Index0.04

Instability Index37.31

Aliphatic Index 53.76

Aromaticity 0.1647

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 13325.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3758.81

LogP -31.41

H-bond Donors 140.0

H-bond Acceptors 139.0

Rotatable Bonds 322.0

Heavy Atoms 692.0

Ring Count 20.0

Amide Bonds 87.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0011479 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZH4/entry; https://bblserver.org.in/ampdb/