Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2435H3872N648O686S19

DescriptionStandard

        MRKDMARGLHDAPRWASLLVLVAVGTTVTAAANPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSGSFKIKLLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKARKRFIKTSGNFDLSVEGMSISADLKLGSNSTSGKPTVSCSSCSSHINSVHVRISKSRVGWLIRLFRKKIESTLRKKLNSQVCEKVTSSVSSELQPYFQTLPVMTEIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHNPPPFAPAVMEFPAAHDRMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIQIHVSASAPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGMSTTGSMEVEAKSDRLVGKLQVDRLVLELKHSNIGPFPVELLQAIMNYIVPTFVLPRVNEKLQKGFPLPTPARVQLYNTVLQPHQNFLLFGADVVYK
    

Molecular Weight53809.96 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)21.45

Net Charge (pH 7.4) 20.52

Charge Density (pH 7.0) 0.0440

GRAVY Index-0.04

Hydrophobic Moment 0.78

Boman Index0.08

Instability Index39.25

Aliphatic Index 90.84

Aromaticity 0.0883

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355905 VERIFIED: NO

Provenance & Taxonomy

OrganismChlorocebus sabaeus [Animal]

FamilyBPI/LBP

Tax ID60711

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria