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MYP_149124
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Basic Information
Al1-d F17-6K
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C89H142N24O18
Standard
Sequence
KKKKKKAAFAAWAAFAA
Physicochemical Analysis
1836.23 Da
10.70
5.75
5.54
0.3385
-0.25
0.24
-0.05
0.57
47.06
0.1765
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
700.83
-3.70
25.0
24.0
63.0
131.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0229685 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
and P.aeruginosa PA381
12.5 μM
MIC
PMID31194548 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31194548/
RECORD: Rec_0233956 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 10 and 14) in sequence indicates 2-(4'-pentenyl) alanine. Ⓧ (10) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
1.0 μM
MIC
PaperTracy A Stone, Gregory B Cole, Huong Q Nguyen, Simon Sharpe, Charles M Deber. Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides. Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. Epub 2017 Oct 21. PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
RECORD: Rec_0262659 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis C621
4 μM
MIC
PMID12384369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12384369/
RECORD: Rec_0279741 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
RECORD: Rec_0284915 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/12384369/ PMID12384369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12384369/
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