Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2199H3463N551O628S14

DescriptionStandard

        MTSLHSSSCCGTTIPSMLQQPKHDRIILKSFNWKAIVASILSMVIRSFQIPSSQISLVPNVGLKLSISGAFIQVDGKWNAHYLVSDKGNFDLKVEGLSISVGLQLGSDASGRPTISSSDCSCHISDVKIHVSGKFRWLVDVFHKSIDNALRKAIEGQLCPVVTQSITNKLQPLLQTLPVTAQIDHVAAIDYSLTGPPTVTAQSLDVQLKGEFFDIAHRTTPPFSPPPVPLPAEQNLMVYFGVSDYLFNTAGYAYYSAGKFESYITDDMIPKNFSVHLNTSSFGILIPQLSKMYPNMPMILKIYTPSAPFLTIEPGNLTTSPIVAIQAYVQFPNASLAPLFLLNLTTTVLVKVSVNSGRIVGSLELSRIKMELVHSDVGPFPVGILNTVVNYYISSIILPEVNEILQKGYPLPLLDHIQLTDVIIKPSEHFLLFGANVQYG
    

Molecular Weight48116.24 Da

Isoelectric Point (pI)6.86

Net Charge (pH 7.0)-0.49

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.0011

GRAVY Index0.24

Hydrophobic Moment 0.78

Boman Index0.20

Instability Index44.77

Aliphatic Index 107.39

Aromaticity 0.0864

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0273304 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria