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MYP_149055
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Basic Information
NK15
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
15 amino acids
C76H145N25O18
Standard
Sequence
KILRGVSKRILTGKK
Physicochemical Analysis
1697.12 Da
12.00
5.76
5.55
0.3837
-0.41
0.68
-0.29
46.95
123.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
739.06
-6.30
28.0
24.0
64.0
119.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0190026 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
256 μg/mL
MIC
PMID17389605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17389605/
RECORD: Rec_0258364 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii ATCC 19606
128 μg/mL
MBC
PMID17389605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17389605/
RECORD: Rec_0274393 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 23716
50 μg/mL
MIC
PMID17389605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17389605/
RECORD: Rec_0336405 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa CUN 4158-02
128 μg/mL
MBC
PMID17389605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17389605/
RECORD: Rec_0352219 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxicity tested Hemolysis tested
Gram-negative bacteria; HeLa cells; human erythrocytes
MIC/MBC; cell-viability assay; hemolysis assay
PaperRationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens. J Biol Chem. 2007;282:14719-14728. PMID17389605
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