Peptide Database

Peptide NameI-10

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC94H158N36O17

DescriptionStandard

        VRRFRRFFLRLRRSV
    

Molecular Weight2064.49 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.73

Net Charge (pH 7.4) 6.52

Charge Density (pH 7.0) 0.4489

GRAVY Index-0.53

Hydrophobic Moment 0.98

Boman Index-0.67

Instability Index178.87

Aliphatic Index 90.67

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.25

LogP -6.85

H-bond Donors 38.0

H-bond Acceptors 24.0

Rotatable Bonds 70.0

Heavy Atoms 147.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0135118 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetHeLa

Activity13.5±1.4 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0354244 VERIFIED: YES