Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length453 amino acids

Chemical FormulaC2236H3603N575O633S18

DescriptionStandard

        MFLCCWLPLVALIPMTLGTNPGVEVRLTEKGLEYGRQLGMASIQQKLKTIKVPDISGSQKVSPIGKVQYSLSNLQIVDVGLPKSALDLVAGTGVRLSIGNAFLHLHGNWRVKYMKIIKDSGSFDLNVNDLTIATSIAIKSDETGRPVVSSVSCKAAVGSASIKFHGGASWLYNLFKDFIDKALRNALQKQICPLVADAVSDLNPRLKTLNVVAKVDQYAEIEYAMVSSPTVSNSSIDLSLKGEFYNIGKHQEPPFSPAAFSLPSQINNMLYIGVSVFTANSAAFVYNTAGALGLYITDDMIPHGFPIRLNTRTFGDFIPQIAKRFPGLMMKLLVKTVKNPVISFEPNNVTVQTTGTETSVSAKLFVTEMRLAGAVTLNKMTLTLGKSYVGEFQVKSLHCILQMVLKVVVIPIVNVELAKGYPLPTLGKMKLVNTQLQVLKDYILIGTDVQFVG
    

Molecular Weight49246.17 Da

Isoelectric Point (pI)9.36

Net Charge (pH 7.0)12.98

Net Charge (pH 7.4) 12.29

Charge Density (pH 7.0) 0.0287

GRAVY Index0.24

Hydrophobic Moment 0.78

Boman Index0.17

Instability Index25.77

Aliphatic Index 107.53

Aromaticity 0.0773

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0234439 VERIFIED: NO

Provenance & Taxonomy

OrganismEtheostoma spectabile [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence