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MYP_148926
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Basic Information
Cmpd 11
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Delivery / Targeting ▸ Targeting ligand ▸ Targeting
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Standard
3 amino acids
C18H38N8O4
Standard
Sequence
KKR
Physicochemical Analysis
430.55 Da
11.17
2.76
2.55
0.9194
-4.10
0.43
-1.84
115.33
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
235.46
-2.11
9.0
7.0
17.0
30.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017701 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0026527 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
Zika virus(ZIKV):inhibition the activity of Zika virus NS2B-NS3 protease
41±3.9 μM
IC50
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0067313 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phenylacetyl
None
Phenylacetyl
Bio-Activity Profile
Antiviral Anti-ZIKV Replication inhibition
Zika virus(ZIKV)
41±3.9 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperSAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease. | Colarusso S, Ferrigno F, Ponzi S, Pavone F, Conte I, Abate L, Beghetto E, Missineo A, Amaudrut J, Bresciani A, Paonessa G, Tomei L, Montalbetti C, Bianchi E, Toniatti C, Ontoria JM. | Bioorg Med Chem. 2022 Mar 1;57:116631. | DOI:10.1016/j.bmc.2022.116631 | PMID:35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0095742 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0230593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 2-[(3,6-Dihydroxy-2,4-dimethoxyphenyl)thio]acetic acid
Bio-Activity Profile
Anticancer
PaperDNA scission chemistry and EPR studies of four new bis(2,6-dimethoxyhydroquinone-3-mercaptoacetic acid)-peptide conjugates Evidence URLhttps://doi.org/10.1071/ch03111
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