Peptide Database

Peptide NameSLAY-screened peptide P5405

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC59H89N17O20S

DescriptionStandard

        PGHSGSPMQYNTL
    

Molecular Weight1388.50 Da

Isoelectric Point (pI)7.17

Net Charge (pH 7.0)0.04

Net Charge (pH 7.4) -0.06

Charge Density (pH 7.0) 0.0034

GRAVY Index-0.93

Hydrophobic Moment 0.09

Boman Index0.06

Instability Index19.10

Aliphatic Index 30.00

Aromaticity 0.0769

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 585.52

LogP -8.37

H-bond Donors 20.0

H-bond Acceptors 22.0

Rotatable Bonds 41.0

Heavy Atoms 97.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0074837 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/