Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length497 amino acids

Chemical FormulaC2469H3919N619O732S17

DescriptionStandard

        MATSPPEIRLNAGRCVLQITGCVEVFAVLPNSTTLYIFVGNLDLKPDSLMLTAAKAVLGLYIIQKLFFDCILLPLVMKQLVKEAAISKQFFSLLSGQLNANPGLKVRITQKGLEYAKEVGLEILKQNMEKEHFPDLTGHEKSGLGNVKYNISSKDSGRGTVHISKVFVTAIFSTPLDNTGPTSISLTSCQTTSGDVDIKLNGKTGFLHNFFIKYLKKPIHRSLVTNSCPNIRAGIQLIDEDLRSLNAVMQIDDLAEVDYSLSSLPAVSQPFIDLDLKGVVFPAGNYTDSPYVAASFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNMTIAEEVAKYSVTPYPVMLKLMSTEIPTISLQQDSFTLEIQGSVEVLAVLPDSTTQSLFTLNIAANTSISLNIFDKKLMGSLCLNRIQFSLAHSNIGSFEVLPLENILSYILQTEVIPSANAKLSKGFPLPNLANVTLTGPHITIVQGYVLISTDVHYKHERKRETTC
    

Molecular Weight54531.34 Da

Isoelectric Point (pI)6.02

Net Charge (pH 7.0)-4.74

Net Charge (pH 7.4) -5.64

Charge Density (pH 7.0) -0.0095

GRAVY Index0.15

Hydrophobic Moment 0.77

Boman Index0.16

Instability Index37.51

Aliphatic Index 103.76

Aromaticity 0.0865

Extinction Coeff. Reduced 25330.00

Extinction Coeff. Oxidized 25705.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0118801 VERIFIED: NO

Provenance & Taxonomy

OrganismHirundo rustica rustica [Bacterium]

FamilyBPI

Tax ID333673

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence