Peptide Database

Peptide NameIpilimumab

Function Ontology

Anticancer

Immunology ▸ Immune checkpoint modulation ▸ Immune checkpoint inhibitor

Immunology ▸ Immunomodulation ▸ Immunotherapy

Standard StatusStandard

Sequence Length243 amino acids

Chemical FormulaC1158H1785N309O354S9

DescriptionStandard

        QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFL
    

Molecular Weight25988.00 Da

Isoelectric Point (pI)8.93

Net Charge (pH 7.0)6.04

Net Charge (pH 7.4) 5.48

Charge Density (pH 7.0) 0.0249

GRAVY Index-0.17

Hydrophobic Moment 0.47

Boman Index0.09

Instability Index51.73

Aliphatic Index 70.53

Aromaticity 0.1029

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44265.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0116692 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunotherapy Immune checkpoint inhibitor

Activity0.2 μg/mL

MethodEC50

Half-LifeTerminal Elimination Half-life: 14.7 -15.4 d